Ephedra was once the most sold dietary supplement in North America. It was widely available and sold without a prescription. Over the years, it was observed by the FDA that the substance was associated with a fair number of complications including heart attacks and deaths. In 2004, FDA banned the sale of ephedra and ephedra-containing products from all health food stores. Today, the sale of ephedra in the USA is illegal. Now that ephedra is gone, it has been replaced with bitter orange.
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